ONE of the following properties of normal cell is lost during its transition to cancerous cell ?

Options

A. Glutamine utilization
B. Contact inhibition
C. Glucose utilization
D. Membrane fluidity

Answer

To solve the question regarding which property of a normal cell is lost during its transition to a cancerous cell, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Properties Listed**: The properties provided in the question are:
- Glutamine utilization
- Contact inhibition
- Glucose utilization
- Membrane fluidity

2. **Analyze Glutamine and Glucose Utilization**:
- Both glutamine and glucose are essential for energy production in cells. Cancerous cells, like normal cells, require energy to grow and divide. Therefore, these properties are not lost during the transition to cancerous cells.

3. **Evaluate Membrane Fluidity**:
- Membrane fluidity refers to the viscosity of the lipid bilayer in cell membranes. This property is generally maintained in both normal and cancerous cells. Thus, it is not the property that is lost during the transition.

4. **Define Contact Inhibition**:
- Contact inhibition is a regulatory mechanism that stops cells from dividing when they come into contact with each other. In normal cells, this process prevents overgrowth and maintains tissue architecture.

5. **Identify the Change in Cancerous Cells**:
- In cancerous cells, the property of contact inhibition is lost. This means that cancer cells can continue to divide uncontrollably even when they are in contact with other cells, leading to tumor formation and metastasis.

6. **Conclusion**:
- The property that is lost during the transition from normal cells to cancerous cells is **contact inhibition**.

### Final Answer:
The property lost during the transition to cancerous cells is **contact inhibition**.

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