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If haemoglobin (Hb) of a normal individu...

If haemoglobin (Hb) of a normal individual and a sickle-cell patient are run in electrophoretic field, they will show

A

Same mobilities

B

Different mobilities

C

Hb of patient will not move at all

D

Hb is immobile

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The correct Answer is:
B
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Write the genotype of (i) an individual who is carrier of sickle cell anaemia gene but apparently unaffected, and (ii) an individual affected with the disease.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell anemia.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.

Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia Sickle cell anemia is a/ an ______________________ disease.

Study the following carefully and explain why mutation (A) did not cuase any sickle cell anemia inspite of change in the molecular structure of the gene which codes for haemoglobin ,when as a similar mutation (B)did. (The question is based on properties of the genetic code.c=codon,a=amino acid ,Hb= Haemoglobin) Amino acids in Hb: a_(1)-a_(2)-a_(3)-a_(4)-a_(5) -Glutamic acid-Glutamic acid- a-(8) ............... (Normal Haemoglobin) Mutation (A): C_(1)-C_(2)-C_(3)-C_(4)-C_(5)-GAA-GAA-C_(8) ...................... a_(1)-a_(2)-a_(3)-a_(4)-a_(5) -Glutamic acid-Glutamic acid- a_(8) .............. (Normal haemoglobin) Mutation (B): C_(1)-C_(2)-C_(3)-C_(4)-C_(5) -GUG-GAA- C_(8) ................... a_(1)-a_(2)-a_(3)-a_(4)-a_(5) -valine-Glutamic acid- a_(8) ............. (Sickle cell Haemoglobin)

ERRORLESS -ANIMAL TISSUES-Animal Tissues
  1. Mark the odd one

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  2. A drop of each of the following, is placed separately on four sides. W...

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  3. If haemoglobin (Hb) of a normal individual and a sickle-cell patient a...

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  4. Which of the following is a type of white blood cell

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  5. Which of the following is absent in blood serum

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  6. Irregular nuclei is present in Or Which white blood cell releases ...

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  7. Which option is correct for the formation of 'Intrinsic factor-X activ...

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  8. Match the following {:(A.,"Neutorphil",1.,"Singal large nucleus"),(B...

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  9. Innate immunity is provided by

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  10. Amount of oxygen supplied by 100 ml arterial blood while passing throu...

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  11. People who have migrated from the planes to an area adjoining Rohtang ...

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  12. Compared to those of humans, the erythrocytes in frog are

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  13. See the following representations and identify the correct blood group...

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  14. Heparin is secreated by

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  15. If pH of blood is artificially changed to 8, what is most likely to ha...

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  16. Erthroposis may be stimulated by the deficiency of

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  17. The figure shows a human blood cell. Identify it and give its charactr...

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  18. Blood cells that increase in number during allergis conditions like as...

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  19. The ratio of RBC to WBC in man is

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  20. Which ones have round and biconcave shape

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