The most susceptible compound to nucleophilic attack at the carboyl carbon among the given bellow is

Options

A. `MeCOCl`
B. `MeCHO`
C. `MeCOOMe`
D. `MeCOOCOMe`

Answer

To determine which compound is most susceptible to nucleophilic attack at the carbonyl carbon, we need to analyze the electron deficiency of the carbonyl carbon in each compound. The more electron deficient the carbonyl carbon is, the more susceptible it will be to nucleophilic attack.

### Step-by-Step Solution:

1. **Identify the Compounds**: We have four compounds to analyze:
- Compound 1: Methyl C=O with Cl
- Compound 2: Methyl C=O with OH
- Compound 3: Methyl C=O with OMe
- Compound 4: Methyl C=O with another carbonyl (C=O)

2. **Analyze Compound 1 (Methyl C=O with Cl)**:
- The chlorine atom (Cl) is highly electronegative and will pull electron density away from the carbonyl carbon.
- This makes the carbonyl carbon more electron deficient, which increases its susceptibility to nucleophilic attack.

3. **Analyze Compound 2 (Methyl C=O with OH)**:
- The hydroxyl group (OH) is less electronegative than Cl and does not withdraw electron density as effectively.
- Therefore, the carbonyl carbon is less electron deficient compared to Compound 1.

4. **Analyze Compound 3 (Methyl C=O with OMe)**:
- The methoxy group (OMe) has lone pairs that can donate electron density to the carbonyl carbon.
- This donation reduces the electron deficiency of the carbonyl carbon, making it less susceptible to nucleophilic attack.

5. **Analyze Compound 4 (Methyl C=O with another carbonyl)**:
- In this case, the presence of another carbonyl group can also pull electron density away, but not as effectively as Cl in Compound 1.
- The electron deficiency is reduced due to the presence of another carbonyl.

6. **Conclusion**:
- Comparing all four compounds, Compound 1 (Methyl C=O with Cl) has the highest electron deficiency at the carbonyl carbon due to the strong electronegative effect of Cl.
- Therefore, it is the most susceptible to nucleophilic attack.

### Final Answer:
**The most susceptible compound to nucleophilic attack at the carbonyl carbon is Compound 1 (Methyl C=O with Cl).**