What is the correct about the axolemma before acquiring the stage of depolarisation ?

Options

A. Negative outside
B. Positive outside
C. Neither Positive nor N negative
D. Initially Positive then negative

Answer

To answer the question about the axolemma before acquiring the stage of depolarization, we need to understand the resting membrane potential of neurons. Here’s a step-by-step breakdown of the solution:

### Step-by-Step Solution:

1. **Understanding the Axolemma**: The axolemma is the membrane surrounding the axon of a neuron. It plays a crucial role in the conduction of nerve impulses.

2. **Resting Membrane Potential**: Before depolarization occurs, the neuron is in a resting state. In this state, the axolemma is polarized, meaning there is a difference in charge across the membrane.

3. **Charge Distribution**:
- Inside the axolemma (the axoplasm) is negatively charged due to the presence of negatively charged proteins and a higher concentration of potassium ions (K+).
- Outside the axolemma is positively charged due to a higher concentration of sodium ions (Na+) and other positive ions.

4. **Conclusion on Charges**: Therefore, before depolarization, the axolemma has:
- **Negative charge inside** (axoplasm)
- **Positive charge outside** (extracellular fluid)

5. **Final Answer**: The correct statement regarding the axolemma before acquiring the stage of depolarization is that it is **negative inside and positive outside**.