A large number of proteins made by the ribosomes get modified in .

Options

A. Lysosomes.
B. Trans face of Golgi apparatus.
C. Cisternae of Golgi apparatus.
D. Smooth endoplasmic reticulum .

Answer

To solve the question "A large number of proteins made by the ribosomes get modified in," we need to identify the correct cellular structure where protein modification occurs.

### Step-by-Step Solution:

1. **Understanding Ribosome Function**:
- Ribosomes are the cellular machinery responsible for synthesizing proteins from amino acids based on the genetic code.

**Hint**: Remember that ribosomes are the sites of protein synthesis.

2. **Identifying Protein Modification Sites**:
- Once proteins are synthesized by ribosomes, they often undergo modifications to become functional. These modifications include folding, glycosylation, and other post-translational modifications.

**Hint**: Think about where proteins go after they are synthesized to become functional.

3. **Considering Cellular Organelles**:
- The main organelles involved in protein modification are the Endoplasmic Reticulum (ER) and the Golgi Apparatus.
- The Rough Endoplasmic Reticulum (RER) is where initial modifications occur, but the Golgi Apparatus is crucial for further processing and sorting of proteins.

**Hint**: Recall the roles of the Rough ER and Golgi Apparatus in protein processing.

4. **Analyzing the Golgi Apparatus**:
- The Golgi Apparatus consists of stacked membrane-bound structures called cisternae. Proteins are modified as they pass through these cisternae.

**Hint**: The Golgi Apparatus has distinct regions where proteins are modified and sorted.

5. **Finalizing the Answer**:
- Given the options, the correct answer is that a large number of proteins made by the ribosomes get modified in the "cistern of the Golgi apparatus."

**Hint**: Focus on the specific part of the Golgi Apparatus where modifications occur.

### Conclusion:
The correct answer to the question is: **Cistern of the Golgi apparatus**.