Which of the following is an incorrect statement about cannabinoids ?

Options

A. Cannabinoids are the group of chemicals that interact with cannabinoids receptors present mainly in brain and gastrointestinal tract.
B. Cannabinoids are naturally obtained from the inflorescence of the Cannabis sativa plant.
C. Cannabinoids includes marijuana, hashish , charas and ganja.
D. Cannabinoids are generally taken by inhalation and oral ingestion, which affects the cardiovascular system of the body.

Answer

To determine which statement about cannabinoids is incorrect, we will analyze each option provided in the question.

### Step-by-Step Solution:

1. **Understanding Cannabinoids**:
- Cannabinoids are a group of chemicals that interact with cannabinoid receptors in the body. These receptors are part of the endocannabinoid system, which plays a role in various physiological processes.

2. **Analyzing the First Statement**:
- The first statement claims that cannabinoids interact with cannabinoid receptors mainly in the brain and the gastrointestinal tract.
- **Evaluation**: While cannabinoid receptors (CB1 and CB2) are indeed present in the brain, they are also found in other organs such as the lungs, liver, and kidneys. The statement incorrectly specifies the gastrointestinal tract as a primary site for these receptors.
- **Conclusion**: This statement is incorrect.

3. **Analyzing the Second Statement**:
- The second statement says that cannabinoids are naturally obtained from the inflorescence of the Cannabis sativa plant.
- **Evaluation**: This statement is correct. Cannabinoids like THC and CBD are indeed derived from the flowers of the Cannabis sativa plant.
- **Conclusion**: This statement is correct.

4. **Analyzing the Third Statement**:
- The third statement mentions that cannabinoids include marijuana, hashish, charas, and ganja.
- **Evaluation**: This statement is also correct as all these substances are forms of cannabis that contain cannabinoids.
- **Conclusion**: This statement is correct.

5. **Analyzing the Fourth Statement**:
- The fourth statement states that cannabinoids are generally taken by inhalation, which affects the cardiovascular system of the body.
- **Evaluation**: This statement is correct. Cannabinoids can be inhaled (e.g., smoking or vaping), and they do have effects on the cardiovascular system.
- **Conclusion**: This statement is correct.

### Final Conclusion:
The incorrect statement about cannabinoids is the **first statement**.