Enzyme peptidyl transferase can be located in :

Options

A. Larger subunit of ribosome
B. mRNA catalyses peptide bond formation
C. Central part of transfer RNA
D. Smaller subunit of ribosome

Answer

To solve the question regarding the location of the enzyme peptidyl transferase, we will analyze the options provided step by step.

### Step-by-Step Solution:

1. **Understanding Peptidyl Transferase**:
- Peptidyl transferase is an enzyme that catalyzes the formation of peptide bonds between amino acids during protein synthesis. It is a crucial component of the ribosome.

2. **Analyzing the Options**:
- **Option 1: Larger subunit of a ribosome**:
- The peptidyl transferase activity is associated with the larger subunit of the ribosome (specifically the 60S subunit in eukaryotes). This is where the peptide bond formation occurs during translation.
- **Option 2: mRNA catalyzed peptide bond formation**:
- This option is incorrect because mRNA serves as a template for protein synthesis but does not catalyze peptide bond formation itself.
- **Option 3: Central part of transfer RNA**:
- This option is also incorrect. Transfer RNA (tRNA) is responsible for bringing amino acids to the ribosome, but it does not contain peptidyl transferase.
- **Option 4: Smaller subunit of ribosome**:
- The smaller subunit (40S in eukaryotes) is involved in the initiation of translation and decoding the mRNA but does not have peptidyl transferase activity.

3. **Conclusion**:
- Based on the analysis, the correct answer is **Option 1: Larger subunit of a ribosome**.

### Final Answer:
The enzyme peptidyl transferase can be located in the **larger subunit of a ribosome**.

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