Which of the following reacts with `CHCl_3 +KOH` ?

Options

A. Adenine & uracil
B. adenanine & lysine
C. adenine and thymine
D. uracil & thymine

Answer

To determine which of the following compounds reacts with chloroform (CHCl₃) in the presence of potassium hydroxide (KOH), we need to understand the carbylamine reaction. This reaction specifically tests for primary amines, which react with chloroform and a strong base to form isocyanides.

### Step-by-Step Solution:

1. **Understanding the Carbylamine Reaction**:
- The carbylamine reaction involves the reaction of chloroform (CHCl₃) with a primary amine in the presence of a strong base like KOH.
- The general reaction can be represented as:
\[ RNH_2 + CHCl_3 + 3KOH \rightarrow R-NC + 3KCl + 3H_2O \]
- Here, \( RNH_2 \) represents a primary amine, which is necessary for the reaction to occur.

2. **Identifying the Compounds**:
- We need to analyze the given options for the presence of primary amines. The options include:
- Option 1: Adenine and Uracil
- Option 2: Adenine and Lysine
- Option 3: Thymine and Adenine
- Option 4: Uracil and Thymine

3. **Analyzing Each Option**:
- **Option 1: Adenine and Uracil**:
- Adenine has a primary amine group (NH₂) and can react positively.
- Uracil has a secondary amine and will not react positively.
- **Conclusion**: This option is incorrect.

- **Option 2: Adenine and Lysine**:
- Adenine has a primary amine group (NH₂) and can react positively.
- Lysine has two primary amine groups (NH₂) and can also react positively.
- **Conclusion**: This option is correct.

- **Option 3: Thymine and Adenine**:
- Adenine has a primary amine group (NH₂) and can react positively.
- Thymine has a secondary amine and will not react positively.
- **Conclusion**: This option is incorrect.

- **Option 4: Uracil and Thymine**:
- Both Uracil and Thymine have secondary amines and will not react positively.
- **Conclusion**: This option is incorrect.

4. **Final Conclusion**:
- The only option that contains compounds that can react positively with CHCl₃ and KOH is **Option 2: Adenine and Lysine**.

### Final Answer:
**Option 2: Adenine and Lysine**