Home
Class 12
CHEMISTRY
Amides undergo hydrolysis to yield carbo...

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution
`(RCH_(2)Broverset(NaCN)to RCH_(2)CN)`
which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols.
The mechanism involved during the hydrolysis of acid derivatives is:

A

elimination-addition

B

addition-elimination

C

nucleophilic addition elimination

D

electrophilic addition elimination

Text Solution

Verified by Experts

The correct Answer is:
C
Promotional Banner

Topper's Solved these Questions

  • ALKENE, ALKANE & ALKYNE

    ALLEN|Exercise EXCERSISE-2|20 Videos
  • AIIMS 2019

    ALLEN|Exercise CHEMISTRY|35 Videos
  • ALKYL AND ARYL HALIDE

    ALLEN|Exercise EXERCISE-05 (B)|37 Videos

Similar Questions

Explore conceptually related problems

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution (RCH_(2)Broverset(NaCN)to RCH_(2)CN) which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols. For which functional derivative of carboxylic acids, acidic hydrolysis is the fastest?

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution (RCH_(2)Broverset(NaCN)to RCH_(2)CN) which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols. Which of the following constitutes the best substrate during the acidic hydrolysis of amides?

Amides undergo hydrolysis to yield carboxylic acid plus amine on heating in either aqueous acid or aqueous base. The conditions required for amide hydrolysis are more severe than those required for the hydrolysis of esters, anhydrides or acid chlorides, but the mechanism is similar (nucleophilic acyl substitution). Nucleophilic acyl substitutions involve a tetrahedral intermediate, hence these are quite different from alkyl substitution (RCH_(2)Broverset(NaCN)to RCH_(2)CN) which involves a pentavalent intermediate or transition state. One of the important reactions of esters is their reaction with two equivalent of Grignard reagent to give tertiary alcohols. When is treated with two equivalent of methyl magnesium iodide and the product acidified the final product will be

Nucleophilic bimolecular substitution involve:

Rate of hydrolysis : ester, acid chloride, acid anhydride

Acyl nucleophilic substitution (SNAC) (SNAE)

Acid halides are more reactive than acid amides towards the hydrolysis.

Hydrolysis of nucleic acid yields

ALLEN-ALKENE, ALKANE & ALKYNE -EXCERSISE-3
  1. Hell-Volhard-Zelinsky reaction involves the replacement of an ...........

    Text Solution

    |

  2. Carboxylic acids may be prepared by the reaction of Grigrand reagents ...

    Text Solution

    |

  3. Statement-I: Unlike the gtC=O group of aldehydes and ketones, the C=O ...

    Text Solution

    |

  4. Statement-I: CH(3)COCH(2)COOC(2)H(5) will give iodoform test. Becau...

    Text Solution

    |

  5. Statement-I: Acetic acid does not undergo haloform reaction. Because...

    Text Solution

    |

  6. Statement-I: Benzoic acid on nitration will give m- nitrao benzoic aci...

    Text Solution

    |

  7. Statement-I: Acyl halide are more reactive than acid substance amide t...

    Text Solution

    |

  8. Amides undergo hydrolysis to yield carboxylic acid plus amine on heati...

    Text Solution

    |

  9. Amides undergo hydrolysis to yield carboxylic acid plus amine on heati...

    Text Solution

    |

  10. Amides undergo hydrolysis to yield carboxylic acid plus amine on heati...

    Text Solution

    |

  11. Amides undergo hydrolysis to yield carboxylic acid plus amine on heati...

    Text Solution

    |

  12. Ester gives nucleophilic addition reaction followed by elimination rea...

    Text Solution

    |

  13. Ester gives nucleophilic addition reaction followed by elimination rea...

    Text Solution

    |

  14. Ester gives nucleophilic addition reaction followed by elimination rea...

    Text Solution

    |

  15. Ester gives nucleophilic addition reaction followed by elimination rea...

    Text Solution

    |

  16. The reactivity of acid derivatives in general follows the order : ...

    Text Solution

    |

  17. The reactivity of acid derivatives in general follows the order : ...

    Text Solution

    |

  18. The reactivity of acid derivatives in general follows the order : ...

    Text Solution

    |

  19. The reactivity of acid derivatives in general follows the order : ...

    Text Solution

    |

  20. The reactivity of acid derivatives in general follows the order : ...

    Text Solution

    |