Select the option which is not correct with respect to enzyme action

Options

A. Substrate binds with enzyme as its active site
B. Addition of lot of succinate does not reverse the inhibition of succinic dehydrogenase by malonate
C. A non-competitive inhibitor binds the enzyme at a site distinct from that which binds the substrate
D. Malonate is a competitive inhibitor of succinic dehydrogenase

Answer

B

Explanation

Option (b) is incorrect with respect to enzyme action because addition of a lot of succinate reverse the inhibition of succinic dehydrogenase by malonate Inhibition of succinic dehydrogenase by malonate is an example of competitive inhibition Competitive inhibition occurs when enzyme and inhibitor both have more or less similar structure and are present in higher concentration. Thus both enzyme and inhibitor compete for the active enzymes resulting in the decrease of the enzymatic activity