Which one of the following hydrolyses internal phosphodiester, bonds in a polynucleotide chain

Options

A. Lipase
B. Protease
C. Endonuclease
D. Exonuclease

Answer

C

Explanation

DNase (deoxyribonuclease) or simply nuclease is an enzyme which breaks down DNA by hydrolysis of the phosphodiester bonds of its sugar-phosphate back bone. Depending on the position of hydrolysing phosphodiester bonds. nucleases are of two types :
(i) Endonucleases (ii) Exonucleases Endonucleases hydrolyse internal phosphodiester bonds in a polynucleotide chain (i.e. DNA). While exonucleases hydrolyse terminal phosphodiester bonds in a polynucleotide chain (i.e. DNA).