Define the following terms in relation to proteins :
Denaturation

Explanation

**Step-by-Step Solution:**

1. **Definition of Denaturation**: Denaturation is a process that involves the alteration of the natural structure of a protein. This alteration primarily affects the secondary and tertiary structures of the protein, which are crucial for its functionality.

2. **Loss of Structure**: In denaturation, the protein loses its three-dimensional (3D) structure that is essential for its biological activity. The native state of the protein, which is its functional form, is disrupted.

3. **Causes of Denaturation**: Denaturation can occur due to various external factors, including:
- **Strong Acids and Bases**: The introduction of strong acids or bases can disrupt the ionic and hydrogen bonds that maintain the protein's structure.
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