Generation of second messengers is not possible in which of the given set of hormones ?

Options

A. Epinephrine, insulin glucagon
B. Estrogen, cortisol, thyroxine
C. FSH, LH, oxytocin
D. Estradiol, oxytocin, FSH

Answer

To determine which set of hormones does not generate second messengers, we need to analyze the types of hormones listed and their mechanisms of action.

### Step-by-Step Solution:

1. **Identify the Types of Hormones**:
- Hormones can be classified into three main categories based on their chemical nature:
- **Peptide Hormones**: These include insulin, glucagon, FSH, LH, and oxytocin. They typically bind to membrane-bound receptors and often generate second messengers.
- **Steroid Hormones**: These include cortisol, estrogen (estradiol), and testosterone. They usually bind to intracellular receptors and do not generate second messengers.
- **Amino Acid Derivatives**: Epinephrine is an example and can generate second messengers.

2. **List the Given Hormones**:
- The hormones mentioned in the question are:
1. Epinephrine
2. Insulin
3. Glucagon
4. Estrogen
5. Cortisol
6. Thyroxine
7. FSH
8. LH
9. Oxytocin
10. Estradiol
11. Oxytocin (repeated)
12. FSH (repeated)

3. **Determine Which Hormones Generate Second Messengers**:
- **Peptide Hormones** (generate second messengers):
- Insulin, Glucagon, FSH, LH, Oxytocin
- **Steroid Hormones** (do not generate second messengers):
- Cortisol, Estrogen (Estradiol)
- **Thyroid Hormones** (do not generate second messengers):
- Thyroxine (T4)
- **Amino Acid Derivative** (generates second messengers):
- Epinephrine

4. **Conclusion**:
- The hormones that do not generate second messengers are primarily the steroid hormones (Cortisol, Estrogen) and the thyroid hormones (Thyroxine). Therefore, the correct answer to the question is the set containing **Cortisol, Estrogen, and Thyroxine**.

### Final Answer:
The generation of second messengers is not possible in the set of hormones that includes **Cortisol, Estrogen, and Thyroxine**.