Which of these is not obtained from a fungus?

Options

A. cyclosporin A
B. statin
C. antibiotic penicillin
D. holes in Swiss cheese

Answer

To solve the question "Which of these is not obtained from a fungus?" we will analyze each option provided.

### Step-by-Step Solution:

1. **Identify the Options**: The options given are:
- Cyclosporine A
- Statin
- Antibiotic Penicillin
- Holes in Swiss Cheese

2. **Analyze Cyclosporine A**:
- Cyclosporine A is an immunosuppressant drug that is produced by the fungus *Trichoderma polysporum*.
- **Conclusion**: Cyclosporine A is obtained from a fungus.

3. **Analyze Statin**:
- Statins are a class of drugs used to lower cholesterol levels. They can be derived from various fungi, including species from the genera *Aspergillus* and *Penicillium*.
- **Conclusion**: Statin is obtained from a fungus.

4. **Analyze Antibiotic Penicillin**:
- Penicillin was the first antibiotic discovered and is produced from the mold *Penicillium notatum*.
- **Conclusion**: Antibiotic Penicillin is obtained from a fungus.

5. **Analyze Holes in Swiss Cheese**:
- The holes in Swiss cheese are primarily caused by the production of carbon dioxide gas during fermentation. This gas is produced by bacteria, specifically *Propionibacterium shermanii*, not fungi.
- **Conclusion**: Holes in Swiss Cheese are not obtained from a fungus.

### Final Answer:
The option that is not obtained from a fungus is **Holes in Swiss Cheese**.

---