The following symptoms correspond to which of the following disorder :
1. Deaf-mutism
2. Abnormal skin
3. Mental retardation in children

Options

A. Myxoedema
B. Cretinism
C. Down's syndrome
D. Grave's disease

Answer

To solve the question regarding the symptoms of deaf-mutism, abnormal skin, and mental retardation in children, we need to analyze the provided options and relate them to the symptoms described.

### Step-by-Step Solution:

1. **Identify the Symptoms**:
- The symptoms given are:
- Deaf-mutism
- Abnormal skin
- Mental retardation in children

2. **Evaluate the Options**:
- The options provided are:
- Myxedema
- Cretinism
- Down Syndrome
- Graves' Disease

3. **Analyze Each Option**:
- **Myxedema**: This is a severe form of hypothyroidism in adults and does not typically present with the symptoms listed.
- **Cretinism**: This is a condition resulting from severe hypothyroidism during pregnancy or early childhood. It is characterized by:
- Mental retardation
- Stunted growth
- Abnormal skin (dry and coarse)
- In some cases, deaf-mutism can also be associated.
- **Down Syndrome**: This genetic disorder is caused by an extra chromosome 21 and is associated with characteristic facial features and varying degrees of intellectual disability, but it does not typically include deaf-mutism or abnormal skin.
- **Graves' Disease**: This is a form of hyperthyroidism and does not relate to the symptoms provided.

4. **Conclusion**:
- The symptoms of deaf-mutism, abnormal skin, and mental retardation in children correspond to **Cretinism**.

### Final Answer:
The disorder corresponding to the symptoms of deaf-mutism, abnormal skin, and mental retardation in children is **Cretinism**.

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