Thalassemia and sickle-cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

Options

A. Both are due to a qualitative defect in global chain synthesis
B. Both are due to a quantitative defect in globin chain synthesis
C. Thalassemia is due to less synthesis of globin molecules
D. Sickle-cells anaemia is due to a quantitative problem of globin molecules

Answer

C

Explanation

Thalassemia is a autosomal recessive disease, which occurs due to mutation in genes. This results in reduced rate of synthesis of the globin chains of haemoglobin. Anaemia is the main feature of this disease. There are two forms of Thalassemia, i.e. `alpha`-thalassemia (production of affected `alpha`-globin chain, which is governed by genes on 16th chromosome). and `beta`-thalassemia (production of affected `beta`-chain, which is governed by a gene on 11th chromosomes).
Concept Enhancer Thalassemia differs from sickle-cell anamia in that the former is a quantitative problem of synthesising few globin molecules, while the later is a qualitative problem of synthesising an incorrectly functioning globin.