The most striking example of point mutation is found in a disease called

Options

A. thalassemia
B. night blindness
C. Down's syndrome
D. sickle-cell anaemia

Answer

D

Explanation

Sickle-cell anaemia is an example of point mutation. It is a genetic disease reported from negroes due to a molecular mutation of gene `Hb^(A)` on chromosome 11 which produces `beta`-chain of adult haemoglobin.
In this disease nucleotide triplet CTC is changed to CAC, these changes takes place at a particular point of chromosome, so they are called as point mutation.