Which of the following statement is true for the packaging of DNA in eukayotes?
A. DNA is packaged with a set of basic protein called histone.
B. Histone contain negatively charged amino acid in its side chain.
C. DNA packed with histone octamer are called nuclesome.
D. Nuclesome is further packed to form chromatin fibre.

Options

A. A, B & C are true
B. A , B , C and D are true
C. B, C and D are true
D. None of these

Answer

To determine which statement is true regarding the packaging of DNA in eukaryotes, let's analyze each option step by step.

### Step 1: Analyze Statement A
**Statement A:** DNA is packaged with a set of basic proteins called histone.
- **Explanation:** This statement is true. In eukaryotic cells, DNA is indeed packaged with histone proteins, which are basic in nature and play a crucial role in the organization and compaction of DNA into a structure known as chromatin.

### Step 2: Analyze Statement B
**Statement B:** Histones contain negatively charged amino acids in their side chain.
- **Explanation:** This statement is false. Histones are basic proteins, and they primarily contain positively charged amino acids such as lysine and arginine. Therefore, this statement does not accurately describe histones.

### Step 3: Analyze Statement C
**Statement C:** DNA packed with histone octamers are called nucleosome.
- **Explanation:** This statement is true. A nucleosome consists of a segment of DNA wound around a core of histone proteins (specifically, an octamer of histones). This structure is fundamental to DNA packaging in eukaryotes.

### Step 4: Analyze Statement D
**Statement D:** Nucleosome is further packed to form chromatin fiber.
- **Explanation:** This statement is also true. Nucleosomes are further organized and compacted to form chromatin fibers, which are essential for fitting the long DNA molecules into the nucleus.

### Conclusion
- The true statements regarding the packaging of DNA in eukaryotes are A, C, and D. However, since the question asks for which statement is true, the most straightforward answer would be **A** as it is the most fundamental aspect of DNA packaging.

### Final Answer
**A. DNA is packaged with a set of basic proteins called histone.**

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