Write a note on denaturation of proteins.

Explanation

(i) Each protein has a unique three- dimensional structure formed by interactions such as disulphide bond, hydrogen bond, hydrophobic and electrostatic interactions.
(ii) These interactions can be disturbed when the protein is exposed to a higher temperature, certain chemicals such as urea, alteration of pH, ionic strength etc., It leads to the loss of the three-dimensional structure partially or completely.
(iii) The process of a protein-losing its higher order structure without losing the primary structure, it called denaturation.
(iv) When a protein denatures, its biological function is also lost.