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From their examination of the structure ...

From their examination of the structure of DNA, What did Watson and Crick infer about the probable mechanism of DNA replication, coding capability and mutation?

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DNA replication:
(i) Watson and Crick proosed the double stranded helical structure of DNA. According to them the most probable mechanism of DNA replication is semi conservative methods.
(ii) During semi conservative method of replication both the strands unwind and separate. one strand acts as the template strand with polarity 3. `to` 5. where the replication is continuous, called template strand. In the other strand and the replication is discontinuous, synthesized in fragments (okazaki fragments) with polarity 5. `to` 3.. This is called lagging strand.
(iii) Newly synthesized complementary nucleotides are paired with the existing nucleotides on the parent strand and covalently bonded together by DNA polymerase. This is possible because of base pair rule.
According to Watson and Crick, the sequence of bases in DNA could be copied by using each of the separate partner strands. The DNA could contain genetic information in coded form in the sequence of bases similar to letters printed in a strip of paper. Changes in genetic information (mutations) could result from errors in copying in which the base sequence of DNA become altered.
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