Linker DNA binds

Options

A. `H_(2) & H_(2)` proteins
B. Nucleosome & H,protein
C. `H_(1)` proteins `H_1` proteins
D. Two successive nucleosomes

Answer

### Step-by-Step Solution:

1. **Understanding Linker DNA**: Linker DNA refers to the stretch of DNA that connects two nucleosomes. It plays a crucial role in the structure of chromatin.

2. **Analyzing the Options**: We need to evaluate each option provided in the question to determine which one correctly identifies what binds the linker DNA.

3. **Option 1 - H2 and H2 Proteins**: This option is incorrect. H2 proteins are part of the core histone proteins that make up the nucleosome, but they do not bind linker DNA.

4. **Option 2 - Nucleosome and H1 Protein**: This option is also incorrect. While H1 is a linker histone that helps in the compaction of chromatin, it does not bind the linker DNA itself. Nucleosomes are the structures that contain the DNA wrapped around histones.

5. **Option 3 - H1 Protein**: This option is incorrect as well. H1 protein is associated with the nucleosome but does not bind the linker DNA directly.

6. **Option 4 - Two Successive Nucleosomes**: This is the correct answer. Linker DNA binds between two successive nucleosomes, connecting them and allowing for the overall structure of chromatin.

7. **Conclusion**: The correct answer is that linker DNA binds two successive nucleosomes.