Prokaryotic cell differs from eukaryotic cell in lacking
(I) Nuclear envelope
(II) Membrane bound cell organelles
(III) Nucleolus
(IV) Histone proteins

Options

A. I,II, III and IV
B. I and II only
C. I, II and III
D. I and III only

Answer

To determine how prokaryotic cells differ from eukaryotic cells, we need to analyze the four given options regarding what prokaryotic cells lack:

1. **Nuclear Envelope**: Prokaryotic cells do not have a nuclear envelope. Instead, their genetic material (DNA) is located in a region called the nucleoid, which is not separated from the cytoplasm by a membrane. In contrast, eukaryotic cells have a well-defined nucleus enclosed by a nuclear envelope.

2. **Membrane-bound Cell Organelles**: Prokaryotic cells lack membrane-bound organelles such as mitochondria, endoplasmic reticulum, and Golgi apparatus. Eukaryotic cells, on the other hand, contain these organelles, which perform specific functions within the cell.

3. **Nucleolus**: Prokaryotic cells do not have a nucleolus. The nucleolus is a structure found within the nucleus of eukaryotic cells and is involved in ribosome production. Since prokaryotes do not have a nucleus, they also do not have a nucleolus.

4. **Histone Proteins**: Prokaryotic cells generally do not have histone proteins associated with their DNA. Eukaryotic DNA is wrapped around histone proteins, forming a complex known as chromatin. This structure helps in the organization and regulation of DNA.

Based on the analysis above, prokaryotic cells lack all four components listed in the options. Therefore, the correct answer is that prokaryotic cells differ from eukaryotic cells in lacking:

**(I) Nuclear envelope**
**(II) Membrane-bound cell organelles**
**(III) Nucleolus**
**(IV) Histone proteins**

Thus, the correct option is **Option number 1**.