Chromatin is constituted with
I. DNA
II. Histones
III. Non-histone proteins
IV. RNA

Options

A. I & II only
B. I,II& III only
C. I,II & IV only
D. I,II,III & IV

Answer

To determine what chromatin is constituted of, we need to analyze the components of chromatin. Let's break it down step by step:

### Step-by-Step Solution:

1. **Understanding Chromatin**:
- Chromatin is a complex of DNA and proteins found in the nucleus of eukaryotic cells. Its primary function is to package DNA into a smaller volume to fit in the cell and to protect the DNA structure and sequence.

2. **Components of Chromatin**:
- Chromatin is primarily made up of:
- **DNA**: This is the genetic material that carries the instructions for the development and functioning of living organisms.
- **Histones**: These are a type of protein that help in the packaging of DNA. They play a crucial role in the structure of chromatin by forming nucleosomes, which are the basic units of chromatin.
- **Non-histone proteins**: These proteins are involved in various functions, including the regulation of gene expression and the organization of chromatin structure.

3. **Evaluating the Options**:
- **I. DNA**: Correct, as DNA is a fundamental component of chromatin.
- **II. Histones**: Correct, as histones are essential proteins that help in the packaging of DNA.
- **III. Non-histone proteins**: Correct, as these proteins also contribute to the structure and function of chromatin.
- **IV. RNA**: Incorrect, as RNA is not a component of chromatin.

4. **Conclusion**:
- Chromatin is constituted of DNA, histones, and non-histone proteins. Therefore, the correct options are I, II, and III.

### Final Answer:
Chromatin is constituted of:
- I. DNA
- II. Histones
- III. Non-histone proteins