Stage of mitosis in which the two chromatids of a chromosome separate from each other?

Options

A. Anaphase
B. Metaphase
C. Telophase
D. Prophase

Answer

To answer the question about the stage of mitosis in which the two chromatids of a chromosome separate from each other, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Process of Mitosis**: Mitosis is the process of cell division that results in two daughter cells with the same number of chromosomes as the parent cell. It consists of several stages: prophase, metaphase, anaphase, and telophase.

2. **Identify the Stages of Mitosis**:
- **Prophase**: The chromatin condenses into visible chromosomes, and the nuclear membrane begins to break down.
- **Metaphase**: Chromosomes align at the metaphase plate, and spindle fibers attach to the kinetochores of the chromosomes.
- **Anaphase**: The centromeres split, and the sister chromatids are pulled apart to opposite poles of the cell.
- **Telophase**: Chromatids reach the poles, and the nuclear envelope begins to reform around each set of chromosomes.

3. **Focus on the Question**: The question specifically asks for the stage where the two chromatids of a chromosome separate from each other.

4. **Analyze Each Stage**:
- In **prophase**, chromatids are still together and condensing.
- In **metaphase**, chromatids are aligned but not yet separated.
- In **anaphase**, the centromeres split, and the chromatids are pulled apart to opposite sides of the cell.
- In **telophase**, the chromatids have already separated and are at opposite poles.

5. **Conclude the Answer**: Based on the analysis, the stage of mitosis in which the two chromatids of a chromosome separate from each other is **anaphase**.

### Final Answer:
**The answer is Anaphase (Option A).**

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