Auto immune disorder affecting neuromuscular junction leading to fatigue, weakening and paralysis of skeletal muscle is :-

Options

A. Muscular dystophy
B. Tetany
C. Gout
D. Myasthenia gravis

Answer

**Step-by-Step Solution:**

1. **Understanding the Question:**
The question asks for an autoimmune disorder that affects the neuromuscular junction, leading to symptoms such as fatigue, weakness, and paralysis of skeletal muscles.

2. **Analyzing the Options:**
We have four options to consider:
- A. Muscular Dystrophy
- B. Tetany
- C. Gout
- D. Myasthenia Gravis

3. **Evaluating Each Option:**
- **Muscular Dystrophy:** This condition involves the degeneration of skeletal muscle due to genetic factors, not an autoimmune response. Therefore, it does not fit the description.
- **Tetany:** This condition is characterized by rapid muscle spasms and is typically caused by low calcium levels in the body. It is not related to the neuromuscular junction or autoimmune disorders.
- **Gout:** Gout is an inflammatory condition caused by the accumulation of uric acid in the body, affecting joints rather than the neuromuscular junction.
- **Myasthenia Gravis:** This is an autoimmune disorder where the immune system attacks the neuromuscular junction, leading to muscle weakness, fatigue, and paralysis.

4. **Identifying the Correct Answer:**
Based on the evaluations, Myasthenia Gravis is the only option that matches the criteria of being an autoimmune disorder affecting the neuromuscular junction and causing fatigue and muscle weakness.

5. **Conclusion:**
The correct answer to the question is **D. Myasthenia Gravis**.

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