If you suspect major deficiency of antibodies in a person, to which of the following would you look for confirmatory evidence?

Options

A. Haemocytes
B. Serum globulins
C. Fibrinogen in plasma
D. Serum albumins

Answer

To confirm a major deficiency of antibodies in a person, follow these steps:

1. **Understand the Role of Antibodies**: Antibodies, also known as immunoglobulins, are proteins produced by the immune system to help identify and neutralize pathogens like bacteria and viruses. A deficiency in antibodies can lead to increased susceptibility to infections.

2. **Identify the Testing Method**: When assessing antibody levels, the most common method is to analyze serum. Serum is the liquid part of blood that remains after coagulation, and it contains various proteins, including antibodies.

3. **Evaluate the Options Provided**:
- **Option A: Hemocytes**: These are immune cells found in invertebrates, not humans. Therefore, this option is incorrect.
- **Option B: Serum Globulins**: This is a group of proteins in the blood serum that includes antibodies. Testing serum globulins can provide direct evidence of antibody levels, making this the correct option.
- **Option C: Fibrinogen in Plasma**: Fibrinogen is a protein involved in blood clotting, not in antibody production. Thus, this option is incorrect.
- **Option D: Serum Albumin**: This protein helps maintain osmotic pressure in the blood and is not related to antibody levels. Therefore, this option is also incorrect.

4. **Conclusion**: Based on the evaluation of the options, the confirmatory evidence for a major deficiency of antibodies in a person would be obtained by testing **serum globulins**.

**Final Answer**: The correct option is **B: Serum Globulins**.

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