Assertion: Chill and high fever occur in malaria.
Reason: Release of toxin, haemozoin from ruptured RBCs in malaria.

Options

A. If both assertion and reason are true and reason is the correct explanation of assertion
B. If both assertion and reason are true but reason is not the correct explanation of assertion
C. If assertion is true but reason is false
D. If both assertion and reason are false

Answer

**Step-by-Step Solution:**

1. **Understanding the Assertion**: The assertion states that "Chill and high fever occur in malaria." This is a well-known symptom of malaria, which is characterized by cyclical fevers and chills.

2. **Understanding the Reason**: The reason provided is that "Release of toxin, hemozoin from ruptured RBCs in malaria" explains why chills and high fever occur. Hemozoin is a byproduct of the digestion of hemoglobin by the malaria parasite, Plasmodium.

3. **Linking the Assertion and Reason**: In malaria, when the Plasmodium parasite infects red blood cells (RBCs), it ruptures them, leading to the release of hemozoin. This hemozoin is toxic and triggers an immune response in the body, which results in the symptoms of chills and fever.

4. **Conclusion**: Both the assertion and the reason are correct. The reason provided accurately explains the assertion. Therefore, the assertion is true, and the reason is true, and the reason supports the assertion.

5. **Final Answer**: Both the assertion and reason are correct, and the reason correctly justifies the assertion.

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