`alpha`-ketoglutaric acid undergoes which of the following reaction to produce succinyl Co-enzyme A?

Options

A. oxidation
B. decarboxylation
C. dehydration
D. oxidative decarboxylation

Answer

To determine which reaction alpha-ketoglutaric acid undergoes to produce succinyl Co-enzyme A, we can follow these steps:

### Step-by-Step Solution:

1. **Identify the Compound and Reaction Context**:
- We are starting with alpha-ketoglutaric acid, which is an intermediate in the Krebs cycle (also known as the TCA cycle or citric acid cycle).

2. **Understand the Transformation**:
- The transformation we are interested in is the conversion of alpha-ketoglutaric acid to succinyl CoA. This is a crucial step in the Krebs cycle.

3. **Determine the Type of Reaction**:
- The process involves the removal of a carboxyl group (decarboxylation) and the oxidation of the remaining molecule. This means that carbon dioxide is released during the reaction, and the remaining structure is oxidized to form succinyl CoA.

4. **Define the Specific Reaction**:
- The specific reaction that occurs is called **oxidative decarboxylation**. In this reaction, alpha-ketoglutaric acid undergoes both oxidation (loss of electrons) and decarboxylation (loss of CO2).

5. **Conclusion**:
- Therefore, the correct answer to the question is that alpha-ketoglutaric acid undergoes **oxidative decarboxylation** to produce succinyl CoA.

### Final Answer:
Alpha-ketoglutaric acid undergoes **oxidative decarboxylation** to produce succinyl Co-enzyme A.

---