The globin portion of the fetal haemoglobin - F is made of

Options

A. Two `alpha` and two `gamma` chains
B. Two `alpha` and one `Beta` chains
C. Two `alpha` and two `Beta` chains
D. Four `beta` chains

Answer

To answer the question regarding the composition of the globin portion of fetal hemoglobin (HbF), we can break down the solution into clear steps:

### Step-by-Step Solution:

1. **Understanding Hemoglobin Types**:
- Hemoglobin is a protein in red blood cells responsible for transporting oxygen. There are different types of hemoglobin, primarily fetal hemoglobin (HbF) and adult hemoglobin (HbA).

2. **Identifying Fetal Hemoglobin**:
- Fetal hemoglobin (HbF) is present in the blood of a developing fetus and is gradually replaced by adult hemoglobin (HbA) after birth, typically by the age of 6 months.

3. **Composition of Fetal Hemoglobin**:
- The globin portion of hemoglobin consists of polypeptide chains. In the case of fetal hemoglobin, it is composed of specific chains.

4. **Chains in Fetal Hemoglobin**:
- Fetal hemoglobin is made up of 2 alpha (α) chains and 2 gamma (γ) chains. This is represented as α2γ2.

5. **Comparison with Adult Hemoglobin**:
- In contrast, adult hemoglobin (HbA) is made up of 2 alpha (α) chains and 2 beta (β) chains, represented as α2β2. The presence of gamma chains in fetal hemoglobin allows it to have a higher affinity for oxygen compared to adult hemoglobin.

6. **Conclusion**:
- Therefore, the globin portion of fetal hemoglobin (HbF) is made of 2 alpha chains and 2 gamma chains.

### Final Answer:
The globin portion of fetal hemoglobin (HbF) is made up of **2 alpha and 2 gamma chains**.

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