Breakdown of oxygemoglobin into oxygen and haemoglobin in the tissues will be increased if

Options

A. Blood pH increases
B. `CO_(2)` in blood decreases
C. Blood pH decreases
D. Free fatty acids decreases in blood

Answer

To solve the question regarding the breakdown of oxyhemoglobin into oxygen and hemoglobin in the tissues, we need to analyze the factors that influence this process. Here’s a step-by-step breakdown:

### Step 1: Understand the Process
- Oxyhemoglobin is formed when hemoglobin binds with oxygen. The breakdown of oxyhemoglobin into oxygen and hemoglobin (dissociation) occurs in tissues where oxygen is needed.

### Step 2: Identify Factors Affecting Dissociation
- The dissociation of oxyhemoglobin is influenced by several factors:
1. **Partial Pressure of Oxygen (PO2)**: Lower PO2 favors dissociation.
2. **Partial Pressure of Carbon Dioxide (PCO2)**: Higher PCO2 favors dissociation.
3. **pH Level**: Lower pH (higher concentration of H+ ions) favors dissociation.
4. **Temperature**: Higher temperatures favor dissociation.

### Step 3: Analyze the Options
- Now, let’s look at the provided options:
a. **Blood pH increases**: Higher pH means lower H+ concentration, which favors the formation of oxyhemoglobin, not dissociation.
b. **CO2 in blood decreases**: Lower CO2 levels favor the formation of oxyhemoglobin, not dissociation.
c. **Blood pH decreases**: Lower pH (higher H+ concentration) favors the dissociation of oxyhemoglobin into oxygen and hemoglobin.
d. **Free fatty acids decrease in blood**: This factor does not significantly influence the dissociation of oxyhemoglobin.

### Step 4: Conclusion
- The correct answer is option **c**: Blood pH decreases, as this condition will increase the breakdown of oxyhemoglobin into oxygen and hemoglobin in the tissues.

### Summary of the Solution:
- The breakdown of oxyhemoglobin into oxygen and hemoglobin in tissues will be increased if **blood pH decreases**.