What will be the change in graph depicting percentage saturation of oxyhaemoglobin and `pO_(2)` (mm of Hg) with increase in `H^(+)` concentration in blood ?

Options

A. Graph shifts to right
B. Graph shift to left
C. No change
D. All of these

Answer

To answer the question regarding the change in the graph depicting the percentage saturation of oxyhemoglobin and partial pressure of oxygen (pO2) with an increase in H⁺ concentration in blood, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Relationship**: Recognize that the saturation of oxyhemoglobin is influenced by several factors, including pH, temperature, and the partial pressures of oxygen (pO2) and carbon dioxide (pCO2).

2. **Identify the Effect of H⁺ Concentration**: An increase in H⁺ concentration in the blood indicates a decrease in pH. Lower pH levels (more acidic conditions) are associated with a reduced affinity of hemoglobin for oxygen, meaning hemoglobin will hold onto oxygen less effectively.

3. **Graph Characteristics**: The graph typically has the percentage saturation of oxyhemoglobin on the y-axis and the partial pressure of oxygen (pO2) on the x-axis. Under normal conditions, this graph is sigmoidal in shape.

4. **Effect of Decreased pH**: When the pH decreases (due to increased H⁺ concentration), the affinity of hemoglobin for oxygen decreases. This results in a rightward shift of the oxyhemoglobin dissociation curve.

5. **Interpreting the Shift**: With the rightward shift, at any given pO2, the percentage saturation of oxyhemoglobin will be lower than it would be at a higher pH (or lower H⁺ concentration). For example, if at a certain pO2 the saturation was 50% at normal pH, it might drop to 30% at lower pH.

6. **Conclusion**: Therefore, the graph depicting the percentage saturation of oxyhemoglobin versus pO2 will shift to the right with an increase in H⁺ concentration in the blood.

### Final Answer:
The graph will shift towards the right.

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