Complete failure of the anteriour lobe of pituitary causes

Options

A. Graves disease
B. Acromegaly
C. Cushing's disease
D. Simmond's disease

Answer

To solve the question regarding the complete failure of the anterior lobe of the pituitary gland and its consequences, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Role of the Anterior Pituitary**:
- The anterior lobe of the pituitary gland produces several hormones that regulate various bodily functions, including growth, metabolism, and stress response.

2. **Identify the Options Provided**:
- The options given are:
- A) Graves disease
- B) Acromegaly
- C) Cushing disease
- D) Simons disease

3. **Analyze Each Option**:
- **Graves Disease**: This condition is primarily related to the thyroid gland and is characterized by symptoms such as weight loss, puffy eyes, and an enlarged thyroid. It is not caused by the failure of the anterior pituitary.
- **Acromegaly**: This disorder results from the hypersecretion of growth hormone, typically due to a tumor in the pituitary gland. It occurs in adults and is not a result of the anterior pituitary's failure.
- **Cushing Disease**: This condition arises from the hypersecretion of cortisol from the adrenal cortex, often due to steroid use or tumors. It does not relate to the anterior pituitary's function.
- **Simons Disease**: This condition is directly linked to the failure of the anterior pituitary gland. It leads to symptoms associated with the underproduction of hormones, resulting in atrophy (reduction in size) of organs such as the liver, kidneys, spleen, and heart.

4. **Conclusion**:
- Based on the analysis, the complete failure of the anterior lobe of the pituitary gland causes Simons disease. Therefore, the correct answer is option D.

### Final Answer:
The complete failure of the anterior lobe of the pituitary causes Simons disease (Option D).