Read the following statements and find out the incorrect statement
a. Insulin acts mainly on hepatocytes while glucagon acts on both hepatocytes and adipocytes.
b. Glucagon stimulates glycogenolysis and gluconeogenesis while insulin stimulates the glycogenesis.
c. The glucose homeostasis in blood is maintained by both insulin and glucagon jointly
d. Prolonged hypoglycemia leads to diabetes mellitus which is associated with loss of glucose through urine and formation of harmful compound known as keton bodies.
e. Diabetic patients are successfully treated with insulin therapy.

Options

A. a and b
B. b and d
C. a and d
D. e,a,b,d,c

Answer

To determine the incorrect statement among the provided options, let's analyze each statement step by step:

### Step 1: Analyze Statement A
**Statement A:** Insulin acts mainly on hepatocytes while glucagon acts on both hepatocytes and adipocytes.

- **Explanation:** Insulin does act on hepatocytes (liver cells), but it also acts on adipocytes (fat cells) to promote glucose uptake and storage. Therefore, the claim that insulin acts mainly on hepatocytes is misleading. Glucagon does act on both hepatocytes and adipocytes, but the emphasis on insulin's action being limited to hepatocytes is incorrect.

**Conclusion:** Statement A is incorrect.

### Step 2: Analyze Statement B
**Statement B:** Glucagon stimulates glycogenolysis and gluconeogenesis while insulin stimulates glycogenesis.

- **Explanation:** This statement is correct. Glucagon promotes glycogenolysis (the breakdown of glycogen to glucose) and gluconeogenesis (the formation of glucose from non-carbohydrate sources). Insulin, on the other hand, stimulates glycogenesis (the conversion of glucose to glycogen).

**Conclusion:** Statement B is correct.

### Step 3: Analyze Statement C
**Statement C:** The glucose homeostasis in blood is maintained by both insulin and glucagon jointly.

- **Explanation:** This statement is also correct. Insulin and glucagon work together to maintain glucose levels in the blood. When blood glucose levels rise, insulin is released to lower them, and when they fall, glucagon is released to raise them.

**Conclusion:** Statement C is correct.

### Step 4: Analyze Statement D
**Statement D:** Prolonged hypoglycemia leads to diabetes mellitus which is associated with loss of glucose through urine and formation of harmful compound known as ketone bodies.

- **Explanation:** This statement is incorrect. Prolonged hypoglycemia (low blood sugar) does not lead to diabetes mellitus. Instead, diabetes mellitus is associated with hyperglycemia (high blood sugar). The symptoms mentioned, such as loss of glucose through urine and formation of ketone bodies, are related to hyperglycemia, not hypoglycemia.

**Conclusion:** Statement D is incorrect.

### Step 5: Analyze Statement E
**Statement E:** Diabetic patients are successfully treated with insulin therapy.

- **Explanation:** This statement is correct. Diabetic patients, especially those with Type 1 diabetes or advanced Type 2 diabetes, often require insulin therapy to manage their blood glucose levels.

**Conclusion:** Statement E is correct.

### Final Conclusion
The incorrect statements are A and D. However, since the question asks for one incorrect statement, the most prominent incorrect statement is **Statement A**.