Congenital heart disease, big and wrinkled tongue are symptoms of

Options

A. Turner's syndrome
B. Klinefelter's syndrome
C. Down's syndrome
D. Patau's syndrome

Answer

**Step-by-Step Solution:**

1. **Identify the Symptoms**: The question mentions two specific symptoms: congenital heart disease and a big, wrinkled tongue.

2. **Understand the Context**: These symptoms are often associated with genetic disorders. We need to determine which genetic disorder corresponds to these symptoms.

3. **Review Genetic Disorders**: Among the known genetic disorders, Down syndrome is recognized for having distinct physical and health-related characteristics.

4. **Link Symptoms to Down Syndrome**:
- Congenital heart disease is commonly observed in individuals with Down syndrome.
- A big and wrinkled tongue (also referred to as a furrowed tongue) is another characteristic feature of Down syndrome.

5. **Confirm Chromosomal Basis**: Down syndrome is classified as a chromosomal disorder due to the presence of an extra copy of chromosome 21 (trisomy 21). This chromosomal abnormality leads to the symptoms observed.

6. **Differentiate from Other Disorders**: Other genetic disorders like Turner’s syndrome, Klinefelter’s syndrome, and Patau’s syndrome have different symptoms and are not associated with the specific symptoms mentioned in the question.

7. **Conclusion**: Based on the symptoms provided and their association with Down syndrome, the correct answer is Down syndrome.

**Final Answer**: Down syndrome (Option C).

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