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Mr. steven is suffering from haemophilia...

Mr. steven is suffering from haemophilia and cystic fibrosis . His father is hetrozygous for cystic fibrosis . The probability of Stavan's sperm having recessive X linked as well as autosomal allele is

A

`(1)/(4)`

B

`(1)/(16)`

C

`(1)/(2)`

D

`(1)/(8)`

Text Solution

AI Generated Solution

The correct Answer is:
To solve the problem, we need to analyze the genetic conditions of Mr. Steven and his father, and then calculate the probability of his sperm carrying both a recessive X-linked allele (for hemophilia) and a recessive autosomal allele (for cystic fibrosis). ### Step-by-Step Solution: 1. **Identify the Genetic Disorders**: - Hemophilia is an X-linked recessive disorder. - Cystic fibrosis is an autosomal recessive disorder. 2. **Determine Mr. Steven's Genotype**: - Since Mr. Steven has hemophilia, he must have the genotype X^hY (where X^h represents the X chromosome with the hemophilia allele). - Since he also has cystic fibrosis, he must have the genotype aa (where 'a' represents the recessive allele for cystic fibrosis). 3. **Identify the Father's Genotype**: - Mr. Steven's father is heterozygous for cystic fibrosis, meaning his genotype is Aa (where 'A' is the normal allele and 'a' is the cystic fibrosis allele). - The father’s genotype for hemophilia is not directly given, but since he is the father of Mr. Steven who has hemophilia, he must have a normal X chromosome (X^H) and a Y chromosome (X^HY). 4. **Gamete Formation**: - Mr. Steven can produce two types of gametes for his X-linked trait: X^h (with hemophilia) and Y (without hemophilia). - For the cystic fibrosis trait, he can produce gametes with the recessive allele 'a' (for cystic fibrosis). 5. **Probability Calculation**: - The probability of Mr. Steven's sperm carrying the X^h allele (for hemophilia) is 1/2 (since he can either pass on X^h or Y). - The probability of his sperm carrying the recessive allele 'a' (for cystic fibrosis) is also 1/2 (since he can either pass on 'a' or 'A'). 6. **Combined Probability**: - Since these two events are independent (the inheritance of the X-linked trait does not affect the inheritance of the autosomal trait), we multiply the probabilities: \[ P(X^h \text{ and } a) = P(X^h) \times P(a) = \frac{1}{2} \times \frac{1}{2} = \frac{1}{4} \] ### Final Answer: The probability of Mr. Steven's sperm having both a recessive X-linked allele (for hemophilia) and a recessive autosomal allele (for cystic fibrosis) is **1/4**. ---
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