Which group present in RNA nucleotide is very reactive and makes RNA liable and easily degradable than DNA?

Options

A. 2-OH' group on the purine base
B. 2-OH' group on ribose sugar
C. 3-OH' group on ribose sugar
D. 4-OH' group on ribose sugar

Answer

To answer the question, "Which group present in RNA nucleotide is very reactive and makes RNA liable and easily degradable than DNA?", we can follow these steps:

### Step-by-Step Solution:

1. **Understanding Nucleotides**:
- A nucleotide consists of three components: a nitrogenous base, a sugar, and a phosphate group.
- In RNA, the sugar is ribose, while in DNA, it is deoxyribose.

2. **Identifying the Sugar Structure**:
- Ribose (in RNA) has a hydroxyl group (-OH) attached to the 2' carbon atom.
- Deoxyribose (in DNA) has a hydrogen atom (H) at the 2' carbon instead of a hydroxyl group.

3. **Analyzing the Reactivity**:
- The presence of the hydroxyl group (-OH) at the 2' position in ribose makes RNA more reactive compared to DNA.
- This hydroxyl group can participate in chemical reactions, making RNA less stable and more prone to degradation.

4. **Conclusion**:
- The reactive group present in RNA that contributes to its liability and degradability is the hydroxyl group (-OH) at the 2' position of the ribose sugar.

### Final Answer:
The group present in RNA nucleotide that is very reactive and makes RNA more liable and easily degradable than DNA is the **2' hydroxyl group (-OH) on ribose sugar**.

---