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Which of the following DNA polymerase of...

Which of the following DNA polymerase of prokaryotes have both `3' rarr 5' " and "5' rarr 3'` exonuclease activity?

A

DNA to Pol II

B

DNA Pol I

C

DNA to Pol IV

D

DNA Pol III

Text Solution

AI Generated Solution

The correct Answer is:
To determine which DNA polymerase of prokaryotes has both `3' to 5'` and `5' to 3'` exonuclease activity, we can analyze the options provided. ### Step-by-Step Solution: 1. **Understanding Exonuclease Activity**: - Exonuclease activity refers to the ability of an enzyme to remove nucleotides from the ends of a DNA strand. There are two types: - **3' to 5' exonuclease activity**: This activity allows the enzyme to remove nucleotides from the 3' end, which is often involved in proofreading. - **5' to 3' exonuclease activity**: This activity allows the enzyme to remove nucleotides from the 5' end, which is involved in RNA primer removal and DNA repair. 2. **Analyzing the Options**: - **DNA Polymerase I**: This enzyme is known to have both 3' to 5' and 5' to 3' exonuclease activities. It is involved in DNA replication and repair processes. - **DNA Polymerase II**: This enzyme primarily has 3' to 5' exonuclease activity and is involved in DNA repair but does not have 5' to 3' exonuclease activity. - **DNA Polymerase III**: This enzyme is the primary replicative polymerase in prokaryotes and has 3' to 5' exonuclease activity but lacks 5' to 3' exonuclease activity. - **DNA Polymerase IV**: This enzyme is involved in DNA repair and has only 3' to 5' exonuclease activity. 3. **Conclusion**: - The only DNA polymerase that exhibits both 3' to 5' and 5' to 3' exonuclease activity is **DNA Polymerase I**. ### Final Answer: **DNA Polymerase I** is the correct answer as it possesses both 3' to 5' and 5' to 3' exonuclease activities.
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