Who developed the technique of synthesising RNA molecules with well defined combination of bases (homopolymers and copolymers) to develop genetic code?

Options

A. Crick
B. Har Gobind Khorana
C. Matthaei
D. Nirenberg

Answer

**Step-by-Step Solution:**

1. **Understanding the Question**: The question asks about the individual who developed a technique for synthesizing RNA molecules with specific combinations of bases, which is crucial for understanding the genetic code.

2. **Identifying Key Terms**: The key terms in the question are "synthesizing RNA molecules," "well-defined combination of bases," "homopolymers," "copolymers," and "genetic code."

3. **Exploring the Options**: The options provided are:
- A. Crick
- B. Hargobind Khurana
- C. Mathai
- D. Nirenberg

4. **Recalling Historical Contributions**:
- Francis Crick is known for the discovery of the structure of DNA and the central dogma of molecular biology but not specifically for synthesizing RNA.
- Hargobind Khurana is known for his work in the field of molecular biology, particularly for developing methods to synthesize RNA and for his contributions to deciphering the genetic code.
- Mathai and Nirenberg also made significant contributions to molecular biology, but their primary focus was not on synthesizing RNA in the context mentioned.

5. **Selecting the Correct Answer**: Based on the historical contributions, Hargobind Khurana is the correct answer as he developed the chemical methods for synthesizing RNA molecules with defined sequences, which helped in understanding the genetic code.

6. **Final Answer**: The answer to the question is B. Hargobind Khurana.

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