Which of the following sequence is correct?
(i) An increase in body fluid volume `rarr` switch off the osmoreceptors `rarr` suppresses the ADH Release
(ii) ADH `rarr` Constricting effect on blood vessel `rarr` B.P. high `rarr` Glomerular blood flow more `rarr` GFR more
(iii) Angiotensinogen `rarr` Angiotensin I `rarr` Angiotensin II `rarr` Adrenal cortex `rarr` Aldosterone
(iv) Angiotensin `rarr` ADH `rarr` GFR more `rarr` Aldosterone `rarr` B.P. high

Options

A. i, ii and iii
B. i, ii and iv
C. ii, iii and iv
D. iii, iv and ii

Answer

To determine which of the sequences presented in the question is correct, we will analyze each sequence step by step based on the physiological processes involved in the regulation of body fluid volume, blood pressure, and the roles of various hormones.

### Step-by-Step Solution:

1. **Sequence (i)**:
- **Statement**: An increase in body fluid volume → switch off the osmoreceptors → suppresses the ADH release.
- **Analysis**: This sequence is correct. When body fluid volume increases, osmoreceptors in the hypothalamus detect this change and become less active, leading to a decrease in the release of Antidiuretic Hormone (ADH) from the posterior pituitary. This results in less water reabsorption in the kidneys and more water being excreted in urine.

2. **Sequence (ii)**:
- **Statement**: ADH → Constricting effect on blood vessel → B.P. high → Glomerular blood flow more → GFR more.
- **Analysis**: This sequence is also correct. ADH causes vasoconstriction of blood vessels, which increases blood pressure (B.P.). An increase in blood pressure can enhance glomerular blood flow, leading to an increase in the Glomerular Filtration Rate (GFR).

3. **Sequence (iii)**:
- **Statement**: Angiotensinogen → Angiotensin I → Angiotensin II → Adrenal cortex → Aldosterone.
- **Analysis**: This sequence is correct. Angiotensinogen, produced by the liver, is converted to Angiotensin I by renin (released from juxtaglomerular cells). Angiotensin I is then converted to Angiotensin II by the action of ACE (Angiotensin-Converting Enzyme). Angiotensin II stimulates the adrenal cortex to release aldosterone, which promotes sodium and water reabsorption in the kidneys.

4. **Sequence (iv)**:
- **Statement**: Angiotensin → ADH → GFR more → Aldosterone → B.P. high.
- **Analysis**: This sequence is incorrect. While Angiotensin II does stimulate the release of ADH, the sequence presented implies a direct effect of Angiotensin on GFR and then leads to aldosterone release, which is not a direct sequence. Aldosterone is released in response to Angiotensin II, but it does not directly increase GFR; rather, it influences sodium and water reabsorption, which can indirectly affect blood pressure.

### Conclusion:
The correct sequences are (i), (ii), and (iii). Therefore, the correct answer is that sequences (i), (ii), and (iii) are correct.