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In sickle cell anaemia-...

In sickle cell anaemia-

A

The mutant haemoglobin molecule undergoes polymerisation under low oxygen tension causing the change in the shape of RBC

B

Substitution of Glutamic acid by valine at the sixth position of the `alpha-`chain of haemoglobin

C

The mutant hamoglobin undergoes polymerization under high oxygen tension causing the chage in shape of RBC

D

`alpha-`globin chain is modified

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The correct Answer is:
A
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