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Which of the following are correct diffe...

Which of the following are correct differences between foetal haemoglobin (Hb-F) and adult haemoglobin (Hb-A) ?
(a) Hb-F has higher affinity for oxygen as compared to Hb-A
(b) The curve of Hb-F occurs towards the left of Hb-A
( c) Hb-F has higher affinity for oxygen as compare to HbA
(d) `P_(50)` valve of Hb-F is less than `P_(50)` valve Hb-A

A

a,b,c,d

B

a,b,d

C

a,b,c

D

b,c,d

Text Solution

AI Generated Solution

The correct Answer is:
To determine the correct differences between fetal hemoglobin (Hb-F) and adult hemoglobin (Hb-A), we will analyze each option provided in the question. ### Step-by-Step Solution: 1. **Understanding Hemoglobin Types:** - Fetal hemoglobin (Hb-F) is the type of hemoglobin found in fetuses, while adult hemoglobin (Hb-A) is the type found in adults. The two types of hemoglobin have different affinities for oxygen. 2. **Analyzing Option (a):** - **Statement:** Hb-F has higher affinity for oxygen as compared to Hb-A. - **Evaluation:** This statement is correct. Hb-F binds oxygen more tightly than Hb-A, which is crucial for fetal development as it allows the fetus to extract oxygen from maternal blood. 3. **Analyzing Option (b):** - **Statement:** The curve of Hb-F occurs towards the left of Hb-A. - **Evaluation:** This statement is also correct. The oxygen dissociation curve for Hb-F is shifted to the left compared to that of Hb-A, indicating a higher affinity for oxygen. 4. **Analyzing Option (c):** - **Statement:** Hb-F has higher affinity for oxygen as compared to Hb-A. - **Evaluation:** This statement is a repetition of option (a) and is correct for the same reasons mentioned above. 5. **Analyzing Option (d):** - **Statement:** The P50 value of Hb-F is less than the P50 value of Hb-A. - **Evaluation:** This statement is incorrect. The P50 value is the partial pressure of oxygen at which hemoglobin is 50% saturated. Since Hb-F has a higher affinity for oxygen, its P50 value is actually lower than that of Hb-A, meaning that Hb-F requires a lower partial pressure of oxygen to achieve 50% saturation. 6. **Conclusion:** - The correct differences between fetal hemoglobin and adult hemoglobin are found in options (a), (b), and (c). Therefore, the correct answer is options A, B, and C. ### Final Answer: The correct options are (a), (b), and (c). ---
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