Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia:
- Both parents have sickle cell trait
- One parent has sickle cell anemia and the other has sickle cell trait
- Both parents have sickle cell anemia
Sickle cell anemia is a/ an ______________________ disease.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia:
- Both parents have sickle cell trait
- One parent has sickle cell anemia and the other has sickle cell trait
- Both parents have sickle cell anemia
Sickle cell anemia is a/ an ______________________ disease.
- Both parents have sickle cell trait
- One parent has sickle cell anemia and the other has sickle cell trait
- Both parents have sickle cell anemia
Sickle cell anemia is a/ an ______________________ disease.
A
X linked
B
autosomal dominant
C
autosomal recessive
D
Y linked
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**Step-by-Step Solution:**
1. **Understanding Sickle Cell Anemia**:
- Sickle cell anemia is a genetic disorder characterized by the production of an abnormal form of hemoglobin known as hemoglobin S. This leads to red blood cells becoming rigid and sickle-shaped instead of their normal round and flexible form.
2. **Cause of Sickle Cell Anemia**:
- The disorder is caused by mutations in the HBB gene, which is responsible for producing the beta-globin subunit of hemoglobin.
3. **Inheritance Pattern**:
- Sickle cell anemia is inherited in a specific manner. For an individual to have sickle cell anemia, both copies of the HBB gene (one from each parent) must be defective. If an individual has only one defective copy, they have sickle cell trait but do not exhibit symptoms of the disease.
4. **Identifying the Type of Disorder**:
- Since sickle cell anemia requires both parents to contribute a defective gene for the disease to manifest, it is classified as a recessive disorder. This means that the normal allele can mask the presence of the defective allele.
5. **Conclusion**:
- Given that sickle cell anemia is inherited in this recessive manner and is not linked to sex chromosomes (X or Y), it is classified as an **autosomal recessive disorder**.
**Final Answer**: Sickle cell anemia is an **autosomal recessive disease**.
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**Step-by-Step Solution:**
1. **Understanding Sickle Cell Anemia**:
- Sickle cell anemia is a genetic disorder characterized by the production of an abnormal form of hemoglobin known as hemoglobin S. This leads to red blood cells becoming rigid and sickle-shaped instead of their normal round and flexible form.
2. **Cause of Sickle Cell Anemia**:
- The disorder is caused by mutations in the HBB gene, which is responsible for producing the beta-globin subunit of hemoglobin.
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Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell anemia.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia The following statements are drawn as conclusions from the above data (Kenya). I. Patients with SCD (Sickle Cell Disease) are less likely to be infected with malaria. II. Patients with SCD (Sickle Cell Disease) are more likely to be infected with malaria. III. Over the years the percentage of people infected with malaria has been decreasing. IV. Year 2000 saw the largest percentage difference between malaria patients with and without SCD. Choose from below the correct alternative.
Sickle cell anaemia is
Sickle cell anaemia is
Sickle cell aneemia is
Sickle-cell anaemia is
Sickle -cell anaemia is:
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