Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia:
- Both parents have sickle cell trait
- One parent has sickle cell anemia and the other has sickle cell trait
- Both parents have sickle cell anemia
If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia:
- Both parents have sickle cell trait
- One parent has sickle cell anemia and the other has sickle cell trait
- Both parents have sickle cell anemia
If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.
- Both parents have sickle cell trait
- One parent has sickle cell anemia and the other has sickle cell trait
- Both parents have sickle cell anemia
If one parent has sickle cell anemia and the other has sickle cell trait, there is __________that their children will have sickle cell anemia and ___________will have sickle cell trait.
A
25 % risk, 75% risk
B
50 % risk, 50% risk
C
75% risk, 25% risk
D
75% risk, 25% risk
Text Solution
AI Generated Solution
The correct Answer is:
To solve the question regarding the inheritance of sickle cell anemia when one parent has sickle cell anemia and the other has sickle cell trait, we can follow these steps:
### Step-by-Step Solution:
1. **Understand the Genetics**:
- Sickle cell anemia is caused by mutations in the HBB gene, leading to the production of hemoglobin S (HbS).
- Individuals with sickle cell anemia have two copies of the mutated gene (SS), while individuals with sickle cell trait have one normal gene and one mutated gene (AS).
2. **Identify the Parents' Genotypes**:
- One parent has sickle cell anemia, which means their genotype is SS.
- The other parent has sickle cell trait, which means their genotype is AS.
3. **Set Up a Punnett Square**:
- Create a Punnett square to visualize the possible genetic combinations for their children.
- The rows will represent the alleles from the sickle cell anemia parent (S, S) and the columns will represent the alleles from the sickle cell trait parent (A, S).
4. **Fill in the Punnett Square**:
- The combinations will be:
- From SS parent: S, S
- From AS parent: A, S
- The resulting combinations will be:
- S from SS and A from AS = SA (sickle cell trait)
- S from SS and S from AS = SS (sickle cell anemia)
- S from SS and A from AS = SA (sickle cell trait)
- S from SS and S from AS = SS (sickle cell anemia)
5. **Analyze the Results**:
- The Punnett square shows:
- 2 out of 4 (50%) combinations result in sickle cell trait (SA).
- 2 out of 4 (50%) combinations result in sickle cell anemia (SS).
6. **Conclusion**:
- Therefore, there is a **50% chance** that their children will have sickle cell anemia and a **50% chance** that they will have sickle cell trait.
### Final Answer:
If one parent has sickle cell anemia and the other has sickle cell trait, there is **50% chance** that their children will have sickle cell anemia and **50% chance** that they will have sickle cell trait.
---
To solve the question regarding the inheritance of sickle cell anemia when one parent has sickle cell anemia and the other has sickle cell trait, we can follow these steps:
### Step-by-Step Solution:
1. **Understand the Genetics**:
- Sickle cell anemia is caused by mutations in the HBB gene, leading to the production of hemoglobin S (HbS).
- Individuals with sickle cell anemia have two copies of the mutated gene (SS), while individuals with sickle cell trait have one normal gene and one mutated gene (AS).
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Sickle cell anemia is caused by
Sickle cell anemia is caused by
A
genes that code for altered hemoglobin that can cause red blood cells to sickle.
B
defective genes that cannot prevent malaria parasites from destroying red blood cells.
C
genes that code for sickle-shaped red blood cells.
D
genes that cause acid levels in the bloodstream to become abnormally high.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell anemia.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell anemia.
A
25 % risk
B
50 % risk
C
75% risk
D
No risk
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia If both parents have sickle cell trait, then there is _______________of the child having sickle cell trait.
A
25 % risk
B
50 % risk
C
75% risk
D
No risk
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Sickle-cell anaemia is
Sickle cell anemia is a genetic disorder where the body produces an abnormal hemoglobin called hemoglobin S. Red blood cells are normally flexible and round, but when the hemoglobin is defective, blood cells take on a “sickle” or crescent shape. Sickle cell anemia is caused by mutations in a gene called HBB. It is an inherited blood disorder that occurs if both the maternal and paternal copies of the HBB gene are defective. In other words, if an individual receives just one copy of the defective HBB gene, either from mother or father, then the individual has no sickle cell anemia but has what is called “sickle cell trait”. People with sickle cell trait usually do not have any symptoms or problems but they can pass the mutated gene onto their children. There are three inheritance scenarios that can lead to a child having sickle cell anemia: - Both parents have sickle cell trait - One parent has sickle cell anemia and the other has sickle cell trait - Both parents have sickle cell anemia Sickle cell anemia is a/ an ______________________ disease.
Sickle cell aneemia is
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