Antibiotic inhibiting interaction between tRNA and mRNA during protein synthesis in bacteria

Options

A. Tetracycline
B. Neomycin
C. Erythromycin
D. Streptomycin

Explanation

To answer the question regarding which antibiotic inhibits the interaction between tRNA and mRNA during protein synthesis in bacteria, we can follow these steps:

### Step-by-Step Solution:

1. **Understand the Role of tRNA and mRNA in Protein Synthesis**:
- During protein synthesis, mRNA carries the genetic code from DNA, while tRNA brings the corresponding amino acids to the ribosome, where they are assembled into proteins.

2. **Identify the Mechanism of Action of Each Antibiotic**:
- **Tetracycline**: This antibiotic inhibits the binding of tRNA to the ribosome, thus preventing the addition of amino acids to the growing polypeptide chain.
- **Streptomycin**: It primarily inhibits the initiation of protein synthesis and can cause misreading of mRNA.
- **Chloramphenicol**: This antibiotic inhibits peptidyl transferase, which is involved in the formation of peptide bonds between amino acids.
- **Neomycin**: This antibiotic also inhibits the binding of tRNA to mRNA, similar to tetracycline.
- **Erythromycin**: It inhibits translocation during protein synthesis but does not directly inhibit the interaction between tRNA and mRNA.
- **Rifampicin and Actinomycin**: These antibiotics inhibit RNA synthesis and do not directly affect the interaction between tRNA and mRNA.

3. **Determine the Correct Answer**:
- Based on the mechanisms described, the antibiotic that specifically inhibits the interaction between tRNA and mRNA is **Neomycin** (Option 2).

### Final Answer:
The antibiotic that inhibits the interaction between tRNA and mRNA during protein synthesis in bacteria is **Neomycin**.