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How are receptor protein located in the ...

How are receptor protein located in the cell membrane ?

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Receptors proteins are embedded in cell membrance in suchh a way that their small part pssessing active sites projects out of the surface of the membrance and opens on the outside region of the cell membrane.
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Which of the following statement are incorrect about receptor proteins? I.Majority of receptor proteins are embedded in the cell membranes II.The active site of receptor proteins opens on the inside region of the cell III.Chemical messengers are received at the binding sites of receptor proteins IV.Shape of receptor does not change during attachment of messenger choose the option with all incorrect statements

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