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Polypeptide chains of two haemoglobin mo...

Polypeptide chains of two haemoglobin molecules are shown below. One of the chains shows an abnormality. Observe the diagram and answer the following questions.

a. Which of the polypeptide chain in haemoglobin is abnormal leading to a disease?
b. What is the reason for this abnormality?
c. What will be the effect of this change in polypeptide chain?

Text Solution

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a. A
b. Substitution of glutamic acid by valine in the` 6^(th)` position of the polypeptide chain.
c. The RBC becomes sickle shaped causing a disease sickle cell anaemia, This affects the oxygen carrying capacity of RBC.
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