Give an account on pyruvic oxidation.

Explanation

Two molecules of pyruvate formed by glycolysis in the cytosol enters into the mitochondrial matix. In respiration this pyruvate with coenzyme A is oxidativelydecarboxylated into acetyl CoA by pyruvate dehydrogenase complex. This reaction is irreversible and produces two molecules of `NADH + H^+ and 2CO_2`. It is also called transition reaction or Link reaction. The reaction of pyruvate oxidation is
`underset(2x CH_3 CO.CoA + 2NADH + 2H^+ + 2CO_2 uarr)underset(darr underset("complex"//Mg^(++))("Pyruvate dehydrogenase"))(2x CH3COCOOH + 2NAD^+ + 2CoA)`