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ELISA is a technique based on the princi...

ELISA is a technique based on the principles of antigen- antibody reactions. Can this technique be used in the molecular diagosis of a genetic disorder such as Phenylketonuria?

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Yes, ELISA test can be done to diagnose phenylketonuria. The affected person does not produce the enzyme phenylalanine hydroxylase. If specific antibodies are developed against the enzyme and ELISA is performed, the unaffected person will show positive result due to antigen and antibody reaction, whereas the affected individual produces negative result. [Note: phenylketonuria is an inherited metabolic disorder that causes the accumulation of Phenylalanine (an amino acid) in body cells due to defect in the synthesizing of an enzyme phenylalanine hydroxylase]
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