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State Lyon's hypothesis....

State Lyon's hypothesis.

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Lyon.s hypothesis states that in mammals the necessary dosage compensation is accomplished by the inactivation of one of the X chromosome in females so that both males and females have only one functions X chromosome per cell.
Mary Lyon suggested that Barr bodies represented an inactive chromosome, which in females become tightly coiled into a heterochromatin, a condensed and visible from of chromatin (Lyon.s hypothesis). The number of Barr bodies observed in cell was one less than the number of X-Chromosome. XO females have no Barr body, whereas XXY males have one Barr body.
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