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Briefly explain the structure of human i...

Briefly explain the structure of human insulin. What was the main challenge for production of insulin using rDNA technique?

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The Human insulin is synthesized by the `beta` cells of Islets of Langerhans in the pancreas. It is formed of 51 aminoacids which are arranged in two polypeptide chains, A and B. The polypeptide chain A has 21 amino acids while the polypeptide chain B has 30 amino acids. Both A and B chains are attached together by disulphide bonds.
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